| % | Meet Record | 1:33.40 | Coffman, Jones, Haralson, Anderson | East Knox | 2010 |
| Lane | Team | Squad | Athlete 1 | Athlete 2 | Athlete 3 | Athlete 4 | Seed | Note |
|---|---|---|---|---|---|---|---|---|
| 2 | South Central | A | Furr | Larios-Chavez | Beverly | Strickland | 1:48.00 | |
| 3 | Bucyrus | A | Pirnstill | Feck | Kalb | Weber | 1:44.00 | |
| 4 | Fredericktown | A | Sipes | Snow | Roush | Estep | 1:35.50 | |
| 5 | Centerburg | A | Clayton | Ballinger | Ball | Indiciani | 1:39.00 | |
| 6 | Upper Scioto Valley | A | Sanders | Brown | Thompson | Underwood | 1:39.00 | |
| 7 | Heritage Classical Academy | A | Baker | Costiuc | Kleppinger | Fister | 1:53.82 |